Barclays has reduced its Q1 2025 estimates for Novo Nordisk, citing lower-than-expected prescription volumes for Wegovy and Ozempic in the U.S. The bank anticipates sales and operating profit to fall 2% and 3% below Bloomberg consensus, projecting 19% constant-currency sales growth for the full year, below Novo's guidance range.Despite recent positive developments, including Wegovy's removal from the FDA's drug shortage list, prescription trends have remained flat. Analysts are cautious about potential guidance cuts depending on volume recovery in the latter part of the year, while Barclays maintains an Overweight rating and a DKK 900 price target, confident in the long-term prospects of the GLP-1 franchise.